Sue is well known as one half of the comedy presenting duo Mel and Sue, and an established and versatile comedienne and presenter in her own right. She studied English at New Hall at the University of Cambridge, graduating in 1990. While at Cambridge, she was a member of the Footlights, where she met Mel Giedroyc. She was Footlights president during the academic year 1990/91. She first came to notice with Mel Giedroyc as Mel and Sue. The duo were short-listed for the Daily Express Best Newcomers Award at the Edinburgh Festival in 1993. After a few years writing for French & Saunders (and occasionally appearing on their BBC series), they hosted a lunchtime show on Channel 4 called Light Lunch, and an early evening version, Late Lunch. She has also been a presenter on Channel 4's RI:SE and appeared in Celebrity Big Brother during 2002 in aid of a number of charities.